论文部分内容阅读
MS是一组以肥胖、高血糖、血脂异常及高血压等为主要特征的症候群,发病机制以IR为核心。代谢性疾病与长期能量正平衡导致的肥胖有关。肥胖实质是一种低度炎症反应,先天免疫反应参与此过程。其中,Toll样受体4(TLR4)可能是肥胖致低度炎症反应的一个关键调节点。本文将阐述TLR4介导的炎症反应与肥胖和1R之间的关系。
MS is a group of obesity, hyperglycemia, dyslipidemia and hypertension as the main features of the syndrome, the pathogenesis of IR as the core. Metabolic disease is associated with obesity caused by long-term energy balance. Obesity is a substance of a low degree of inflammatory response, innate immune response involved in this process. Among them, Toll-like receptor 4 (TLR4) may be a key regulator of the obesity-induced low-grade inflammatory response. This article will describe the relationship between TLR4-mediated inflammation and obesity and 1R.