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迷路炎性骨化是膜迷路腔的病理性变化。常发生于炎症反应过程中,它损坏膜迷路或耳囊(otic capsule)的骨内膜。化脓性迷路炎是最常见的原因,其他如肿瘤、耳硬化症、颞骨骨折及内耳出血。化脓性迷路炎可通过以下三条径路之一发生感染:血源性(败血性)、脑膜源性或鼓室源性。组织病理学研究指出迷路炎性骨化是化脓性迷路炎的后果。内耳感染可引起短时间的浆液纤维渗出,并很快化脓及膜性组织的液化和坏死,内、外淋巴腔充满成纤维肉芽组织。成骨细胞从有病变的间叶组织中产生,如骨内膜、蜗轴及基底膜,并长入纤维组织块中,骨化由此形成。
Lost inflammatory ossification is the pathological changes of the labyrinth cavity. Often occurs during the inflammatory reaction, it damages the lining of the membrane or the otic capsule. Suppurative labyrinthitis is the most common cause, others include tumors, otosclerosis, temporal bone fractures, and bleeding in the inner ear. Suppurative labyrinthitis can develop through one of three pathways: hematogenous (septic), meningeal, or tympanic. Histopathological studies have pointed out that the lost inflammatory ossification is the consequence of purulent labyrinthitis. Infection in the inner ear can cause short-term serous fiber exudation, and soon purulent and membranous tissue liquefaction and necrosis, internal and external lymphatic cavity filled with fibrous granulation tissue. Osteoblasts develop from diseased mesenchymal tissue, such as the endosteum, the worm shaft, and the basement membrane, and grow into fibrous tissue mass, forming ossification.