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IgA肾病以肾小球系膜区IgA沉积为特征,是我国乃至亚裔人群中最常见的原发性肾小球疾病[1],典型的临床特点是上呼吸道黏膜感染后立即出现肉眼血尿,提示天然免疫参与了IgA肾病的发病。最近Cox等[2]的研究解释:外界抗原刺激可以引起IgA肾病患者循环中NK细胞、CD8+T细胞和γδ-T细胞高表达CX3C趋化因子受体1
IgA nephropathy is characterized by IgA deposition in the glomerular mesangial area and is the most common primary glomerular disease in China and even in Asian populations [1]. The typical clinical feature is gross hematuria immediately after upper respiratory mucosal infection, Suggesting that innate immunity is involved in the pathogenesis of IgA nephropathy. Recently Cox et al [2] study explained: External antigen stimulation can cause IgA nephropathy in patients with circulating NK cells, CD8 T cells and γδ-T cells highly express CX3C chemokine receptor 1