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建立了可用于被动式微混合器设计的宏微建模方法,利用分离变量法建立用于求解直通道内样品浓度分布的宏模型,采用宏模型计算微混合器的各段直通道内样品的浓度分布.运用有限元方法数值求解复杂的混合单元内样品的浓度分布,通过数值拟合和插值,交换宏模型与数值求解的计算结果.经过反复迭代,实现被动式微混合器的系统级求解.采用数控铣削在聚甲基丙烯酸甲脂(PMMA)平板上加工微通道,用热键合的方法实现微混合器盖片与基片的封装.在微混合器入口,输入3种不同浓度的荧光素钠盐溶液,形成样品浓度的准正态分布.采用激光诱导荧光观察和分析样品的混合效果.通过对比数值仿真和实验测试结果,验证了宏微建模计算方法的准确性.
A macroscopic modeling method that can be used in the design of passive micromixer was established. The macromodel was established by using the separation variable method to calculate the concentration distribution in the straight passage. The macromodel was used to calculate the concentration distribution in the straight passage of the micromixer. The finite element method is used to numerically solve the concentration distribution of samples in a complex mixing unit. The numerical results are interpolated and interpolated to exchange the results of the macromodels and numerical solutions. After repeated iterations, the system level solution of the passive micromixer is realized. Microcapsules were fabricated on polymethylmethacrylate (PMMA) plates, and the micro-mixer coverslips and substrates were encapsulated by hot-bonding.In the micro mixer inlet, three different concentrations of fluorescein sodium salt Solution to form a quasi-normal distribution of the sample concentration.Laser-induced fluorescence was used to observe and analyze the mixing effect of the samples.The numerical simulation and experimental test results were compared to verify the accuracy of the macro-micro modeling method.