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长期以来,关于雄激素的代谢及其对效应器官的作用原理、雄激素依赖性疾病的治疗以及男用避孕药的探讨等问题,进行了许多工作,但还存在不少问题,由于雄激素拮抗药的问世,对进一步研究上述问题提供了新的有效武器。迄今见诸于文献的抗雄激素类固醇与类固醇化合物约有200多种,但绝大多数在临床和实验研究中都无重要价值,仅6-氯-17-羟基-1,2α-次甲基-4,6-妊二烯-3,20-二酮(简称赛泼罗妥龙)及6-氯-17-羟基-1,2α-次甲基-4,6-妊二烯-3,20-二酮-17α-醋酸酯(简
For a long time, much work has been done on the metabolism of androgens and its mechanism of action on the effector organs, the treatment of androgen-dependent diseases, and the exploration of male contraceptives. However, there are still many problems due to androgen antagonism The advent of medicine has provided new and effective weapons for further research on the above issues. So far in the literature about anti-androgen steroids and steroids about 200 kinds, but the vast majority of clinical and experimental studies have no important value, only 6-chloro-17-hydroxy-1,2α-methine 4,6-propadiene-3,20-dione (hereinafter referred to as saetholteopron) and 6-chloro-17-hydroxy-1,2α-methine-4,6-propadiene- 20-dione-17α-acetate (Jane