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目的 探讨雌激素受体亚型的表达与子宫平滑肌瘤发生、发展的关系。方法 将60例子宫肌瘤患者分为AB两组, A组32例<48岁,B组28例>48岁,应用原位杂交技术测定平滑肌瘤组织中雌激素两种受体亚型mRNA的表达,取肿瘤周 围正常的平滑肌作对照。结果 子宫肌瘤组织中ERαmRNA的表达明显高于正常的平滑肌组织,而ERβmRNA的表达降 低;B组ERαmRNA在子宫平滑肌瘤组织中的表达较A组呈下降趋势,而ERβmRNA的表达呈上升趋势。结论 子宫肌瘤的 发生发展与ERαmRNA的高表达有关,亦与ERβmRNA表达减少有关。肌瘤的萎缩可能与ERβmRNA表达的升高趋势及 ERαmRNA表达的下降趋势均相关。
Objective To investigate the relationship between the expression of estrogen receptor subtypes and the occurrence and development of uterine leiomyomas. Methods Sixty cases of uterine fibroids were divided into two groups: A group of 32 cases <48 years old, B group of 28 cases> 48 years old. The expression of estrogen receptor subtype mRNA in leiomyoma was detected by in situ hybridization The expression of normal smooth muscle around the tumor as a control. Results The expression of ERαmRNA in uterine fibroids was significantly higher than that in normal smooth muscle tissues, while the expression of ERβmRNA was decreased. The expression of ERαmRNA in B group was lower than that in group A, but the expression of ERβmRNA was up-regulated. Conclusion The occurrence and development of uterine fibroids are related to the overexpression of ERαmRNA and the decrease of ERβmRNA expression. Atrophy of fibroids may be related to the rising trend of ERβmRNA expression and ERαmRNA expression.