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1963年,Berg发现LDL中混有另一种脂蛋白,并将其命名为脂蛋白(a)。该物质的一些理化性质在70年代早期已为人们所知,但这种脂蛋白的重要性却一直未被人们认识到。直到最近人们发现了脂蛋白(a)和血纤溶酶原有很强的同源性以及它与动脉粥样硬化的密切关系后,这个被冷落了二十多年的脂蛋白才重新被人们所重视,成为生化工作者、尤其是医学工作者所瞩目的研究对象。现将脂蛋白(a)的结构、功能、遗传及其临床意义的有关文献综介如下。
In 1963, Berg found that another type of lipoprotein was mixed with LDL and named it lipoprotein (a). Some of the physical and chemical properties of this material have been known since the early 1970s, but the importance of this lipoprotein has never been recognized. Until recently, lipoprotein (a) was found to have strong homology to plasminogen and its close association with atherosclerosis, the lipoprotein, which had been left for more than 20 years, Attention, as biochemical workers, especially medical workers are attracted by the research object. Now lipoprotein (a) structure, function, genetic and clinical significance of the relevant literature summarized below.