过去,对于局部用药的透皮研究往往集中在影响药物通过皮肤的理化因素,而完全忽视了皮肤酶的代谢能力;最近,很多体内外实验表明,皮肤代谢可能显著地影响局部用药的作用、毒性和吸收.大量文献表明,皮肤对很多化合物都有代谢能力.表皮层中酶含量高,是人类和其他种类动物的主要代谢部位,而大部分化合物在真皮层的停留时间比表皮层短,故与真皮层酶的接触极为短暂.皮肤的特殊组织如皮脂腺、汗腺和毛囊也具有一定的代谢能力,对于某些酶来说,皮脂腺是皮肤中代谢活性最强的组 In the past, transdermal studies of topically applied drugs have focused on physicochemical factors that affect the passage of drugs through the skin, completely neglecting the metabolic capacity of the dermal enzymes; recently, many in vivo and in vitro experiments have shown that skin metabolism can significantly affect the effects of topical drug use, toxicity And absorption of a large number of literatures show that the skin metabolism of many compounds have high levels of enzymes in the epidermis of the human and other types of animals is the main metabolic site, while most of the compounds in the dermis of the residence time shorter than the epidermis, so Contact with the dermal layer enzyme is extremely short, and special tissues of the skin, such as sebaceous glands, sweat glands and hair follicles, also have some metabolic capacity. For some enzymes, sebaceous glands are the most metabolically active group in the skin