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目的探讨组织因子(Tissuefactor,TF)在结肠癌表达的临床意义。方法用RT-PCR和免疫组织化学方法分别检测TF在12例结肠癌旁组织、结肠癌组织中mRNA和蛋白抗原的表达。HPIAS图像分析各组标本相对密度,t检验各组相对密度差异。结果TFmRNA在癌旁组织中低表达,在结肠癌组织中伴有淋巴结转移和肝转移者TFmRNA表达明显高于无转移者,P<0.05。TF蛋白抗原在癌旁组织呈阴性和弱阳性,在伴有淋巴结和肝转移组阳性表达率为83.33%,高于无转移组66.67%,有差别,但无统计学意义。TF表达与肿瘤的转移力高度相关。结论TF是反映结肠癌进展和生物学特性的指标,是临床上判断预后指标之一。
Objective To investigate the clinical significance of Tissue factor (TF) expression in colon cancer. Methods RT-PCR and immunohistochemistry were used to detect the expression of mRNA and protein antigen in 12 cases of colorectal cancer tissues and colon cancer tissues respectively. HPIAS image analysis of the relative density of each group of specimens, t test the relative density of each group differences. Results The expression of TF mRNA in paracancerous tissues was lower than that in non-metastatic tissues (P <0.05). The expression of TF mRNA was significantly higher in colon cancer tissues with lymph node metastasis and liver metastasis. The positive rate of TF protein antigen was negative and weakly positive in paracancerous tissues. The positive rate of TF protein was 83.33% in lymph node and liver metastasis group, which was higher than 66.67% in non-metastasis group, but not statistically significant. TF expression is highly correlated with tumor metastasis. Conclusion TF is an indicator of the progress and biological characteristics of colon cancer and is one of the prognostic indicators in clinical practice.