自1957年英国伦敦国立医学研究所的Allck Iaacs和Jean Lindenman发现干扰素(IFN)以来,迄今已有30多年的研究历史。但IFN的临床治疗始于70年代中、后期。早期研究因自然IFN量少、纯度低,观察病例少,故临床疗效未能得到肯定。随着IFN研究的深入发展,80年代初重组IFN(rIFN)开始问世,国内外能生产一定量的高纯度高效价IFN供临床试用,使IFN治 Since the discovery of interferon (IFN) by Allck Iaacs and Jean Lindenman of the National Medical Research Institute in London in 1957, there have been more than 30 years of research history. However, the clinical treatment of IFN began in the mid and late 70’s. In the early studies, because of the low natural IFN, low purity, and low number of observed cases, the clinical efficacy was not confirmed. With the in-depth development of IFN research, recombinant IFN (rIFN) began to appear in the early 1980s, and a certain amount of high-purity, high-efficiency IFNs can be produced at home and abroad for clinical trials and IFN treatment.