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DNA甲基化是非DNA序列变化所致的基因修饰作用,这种基因修饰作用可在细胞分裂中进行遗传并影响DNA和其他分子的相互作用。DNA甲基化发生在CpG双核苷酸序列内,其5′端的胞嘧啶环在复制完成后添加一个甲基,导致DNA结合蛋白结合的部位即DNA双螺旋凹槽的外形发生改变。DNA甲基化不但与肿瘤的发生有关,还与许多其他疾病如动脉粥样硬化、糖尿病、阿尔茨海默病等相关联。本文对DNA甲基化与非肿瘤性疾病的关系予以综述。
DNA methylation is a non-DNA sequence change caused by the role of genetic modification, this gene modification can be inherited in cell division and affect DNA and other molecular interactions. DNA methylation occurs within the CpG dinucleotide sequence and a cytosine ring at the 5 ’end adds a methyl group after replication is complete, resulting in a change in the appearance of the DNA double helix groove where the DNA binding protein binds. DNA methylation is not only related to tumorigenesis, but also associated with many other diseases such as atherosclerosis, diabetes and Alzheimer’s disease. This article reviews the relationship between DNA methylation and non-neoplastic disease.