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目的观察阿昔洛韦治疗儿童传染性单核细胞增多症患儿的临床效果。方法将医院儿科治疗的儿童传染性单核细胞增多症患儿106例,随机分为观察组和对照组,每组53例。对照组给予α-干扰素治疗,观察组给予阿昔洛韦治疗,观察2组患儿的治疗效果、症状改善时间、不良反应发生情况。结果观察组治疗总有效率为96.23%,高于对照组的77.36%(P<0.05);观察组肝脾肿大恢复时间、颈部淋巴结消退时间、退热时间、咽颊炎症状消失时间、异型淋巴细胞<10%时间、住院时间均短于对照组(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论阿昔洛韦对儿童传染性单核细胞增多症的治疗效果更佳,对症状的改善更为明显,且安全性高,值得在临床推广应用
Objective To observe the clinical effect of acyclovir in children with infectious mononucleosis. Methods A total of 106 pediatric children with infectious mononucleosis syndrome treated by the hospital were randomly divided into observation group and control group, with 53 cases in each group. The control group was treated with α-interferon. The observation group was treated with acyclovir. The therapeutic effect, symptom improvement time and adverse reactions of the two groups were observed. Results The total effective rate of the observation group was 96.23%, which was higher than that of the control group (77.36%, P <0.05). The recovering time of hepatosplenomegaly, neck lymph node subsidence time, antipyretic time, disappearance of pharyngeal cheilitis symptom, Allogeneic lymphocytes <10% of the time, hospital stay were shorter than the control group (P <0.05); no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion acyclovir treatment of children with infectious mononucleosis more effective, the more obvious improvement of the symptoms, and high safety, it is worth in the clinical application