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1例55岁男性患者有2型糖尿病史2年、高血压病史4年,服用瑞格列奈2mg,3次/d、阿卡波糖50mg,3次/d、二甲双胍500mg,3次/d、硝苯地平控释片30mg,1次/d和福辛普利10mg,1次/d治疗。因血糖控制不佳,加用罗格列酮4mg/d,瑞格列奈由2mg,3次/d增至3mg,3次/d。治疗1周后,患者双手掌及足底皮肤出现表皮硬化、开裂,且有表皮脱落、伴疼痛。诊断为剥脱性角质松解症。考虑与罗格列酮有关,停用罗格列酮,其他药物继续使用,给予维生素C和复合维生素B治疗。3d后脱皮好转,3周后皮肤恢复正常。
A 55-year-old man with a history of type 2 diabetes mellitus 2 years and a history of hypertension of 4 years took repaglinide 2 mg 3 times daily, acarbose 50 mg 3 times daily, metformin 500 mg 3 times daily , Nifedipine controlled release tablets 30mg, 1 / d and fosinopril 10mg, 1 / d treatment. Because of poor blood glucose control, plus rosiglitazone 4mg / d, repaglinide by 2mg, 3 times / d to 3mg, 3 times / d. After one week of treatment, the patient had epidermal sclerosis, dehiscence on both palms and plantar skin, with exfoliation and pain. Diagnosis of exfoliative keratolysis. Consider rosiglitazone-related, disable rosiglitazone, other drugs continue to use, given vitamin C and vitamin B treatment. Skin peeling improved after 3d, 3 weeks after the skin returned to normal.