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中药小儿七珍丸含有雄黄和朱砂等成分,用于治疗小儿急性惊风和便秘等症。本文报道2例成人长期大量服用小儿七珍丸致慢性砷中毒。例1,女,36岁。因便秘服用小儿七珍丸40～80粒,1次/d,共3年。在开始服药2～3个月后,患者出现乏力、纳差、腹部皮肤黑变。近1年来出现头晕、头痛、失眠、肢端麻木。入院后,查体示:面部、躯干及四肢色素沉着、手掌及足底皮肤增厚,血砷为7.3μg/L,尿砷为0.117mg/L。诊为慢性砷中毒。患者经用二巯丙磺钠治疗3个疗程后症状明显减轻。例2,男,40岁。因便秘服用小儿七珍丸20～80粒,每天1～2次,共7年。用药后患者逐渐出现乏力、纳差、恶心、腹胀、全身皮肤色素沉着、皮肤过度角化、手足麻木、肝脾肿大、贫血,尿砷为4.28mg/L。诊为慢性砷中毒。患者经用二巯丙磺钠治疗5个疗程后,症状明显减轻出院。
Chinese medicine Zhentiao contains realgar and cinnabar and other ingredients for the treatment of children with acute shock and constipation embolism. This article reports two adults taking long-term large quantities of children Ching Zhen Wan chronic arsenic poisoning. Example 1, female, 36 years old. Due to constipation taking children Qi Zhen Wan 40 to 80 tablets, 1 time / d, a total of 3 years. In the beginning of medication 2 to 3 months later, patients with fatigue, anorexia, abdominal skin blackening. Dizziness, headache, insomnia, limb numbness in the past year. After admission, examination showed: face, trunk and extremities pigmentation, thickening of the skin of the palm and plantar, blood arsenic was 7.3μg / L, urinary arsenic was 0.117mg / L. Diagnosed as chronic arsenic poisoning. Symptoms were significantly reduced after 3 courses of treatment with sodium dimercaptopropane sulphate. Example 2, male, 40 years old. Due to constipation taking children Qi Zhen Wan 20 to 80 tablets, 1 to 2 times a day for a total of 7 years. After treatment, patients gradually developed fatigue, anorexia, nausea, bloating, systemic skin pigmentation, skin hyperkeratosis, numbness of hands and feet, hepatosplenomegaly, anemia, urinary arsenic was 4.28mg / L. Diagnosed as chronic arsenic poisoning. After treatment with 5-mercaptopropristate for 5 courses, the symptoms were relieved and discharged.