中科院大连化学物理所万伯顺研究组在催化杂环合成研究中取得新进展:通过金属铑催化炔烃与硝酮的环加成反应实现了桥联八元杂环化合物的合成,该研究组继吡啶化合物和吡咯化合物的合成研究工作后,尝试利用硝酮来构建中环杂环化合物。在铑催化剂条件下,炔烃与硝酮发生形式上的[2+2+5]环化反应,构建出氧桥联的八元含氮杂环 Progress Made in Research on Catalytic Heterocycle Synthesis Made by CAS Research Group, Dalian Institute of Chemical Physics, Chinese Academy of Sciences: The synthesis of bridged 8-membered heterocyclic compounds has been achieved through the metal cycloaddition reaction of alkynes with nitrones. Following the synthesis of pyridine compounds and pyrrole compounds, we tried to use nitrones to construct heterocyclic compounds. Under rhodium catalyst, the formal [2 + 2 + 5] cyclization reaction of alkyne with nitrones leads to the formation of oxygen bridged 8-membered nitrogenous heterocycle