论文部分内容阅读
作者对两组以往未治疗过的多菌型麻风(每组20例)用两种治疗方案治疗一年。A方案为利福平(RFP)600mg,每周2次,共6个月和氨苯砜100mg/d半年;B方案为RFP600mg每周2次,共6个月、PTH500mg/d共6个月和氨苯砜100mg/d共一年。以上治疗结束后给予安慰剂,治疗期间每3、6及12个月时作临床及细菌检查,以后每年至少检查一次。对可供分析的A组15例和B组14例病人分别随访了4.5年和5年。结果显示这些病人临床进步很快,皮肤涂片检查细菌指数(BI)在停止治疗后每年下降一个单位。A组1例在48个月皮肤涂
The authors treated two groups of previously untreated, multi-bacteria leprosy (20 in each group) for two years with one treatment. A program for rifampicin (RFP) 600mg, twice a week for 6 months and dapsone 100mg / d for six months; B program RFP600mg twice a week for a total of 6 months, PTH500mg / d for 6 months And dapsone 100mg / d a year. Placebo was given at the end of the above treatment, with clinical and bacterial tests performed every 3, 6 and 12 months after treatment and at least once per year thereafter. Fifteen patients in group A and 14 patients in group B were followed up for 4.5 years and 5 years, respectively, for analysis. The results showed that these patients progressed rapidly and that the biopsy bacterial index (BI) decreased by one unit per year after stopping treatment. One patient in group A was dermatologically applied at 48 months