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目的探讨牙齿缺失与食管癌生存的关系。方法采用前瞻性随访的方法,对来自林县营养干预试验一般人群的2743名食管癌患者随访观察24年,基线调查内容包括一般人口学信息、吸烟、饮酒、身高、体重、牙齿缺失状况等信息,Cox回归分析牙齿缺失与食管癌生存的关系。结果 5年随访研究结果表明,调整可能的混杂因素后,牙齿缺失暴露与食管癌死亡风险有统计学关联,RR=1.11(95%CI:1.01,1.21)。随访满15年和24年的研究结果与5年随访研究结果相似。将牙齿缺失情况分为三组,Ⅰ级、Ⅱ级、Ⅲ级,进一步分析。5年、15年、24年随访的研究结果也相似,男性牙齿缺失Ⅲ级均与食管癌的死亡风险有关,RR值分别为1.21(95%CI:1.01,1.44)、1.18(95%CI:1.00,1.40)和1.26(95%CI:1.06,1.50)。而女性牙齿缺失Ⅱ级、Ⅲ级与食管癌的死亡风险无关。结论男性牙齿缺失严重者食管癌死亡风险可能增加,而女性牙齿缺失与食管癌的生存可能无关。
Objective To explore the relationship between tooth loss and esophageal cancer survival. Methods 2743 esophageal cancer patients from Linxian Nutritional Intervention Trial were followed up for 24 years. The baseline survey included demographic information, smoking, alcohol consumption, height, weight and missing tooth status Cox regression analysis of the relationship between tooth loss and esophageal cancer survival. Results Five-year follow-up The results of the study showed that there was a statistically significant association between loss of tooth exposure and risk of death from esophageal cancer after adjustment for possible confounding factors, RR = 1.11 (95% CI: 1.01, 1.21). Follow-up of 15 years and 24 years of the study results and 5-year follow-up study similar. Dental loss will be divided into three groups, Ⅰ, Ⅱ, Ⅲ, further analysis. Results of 5-year, 15-year and 24-year follow-up were also similar. Deletion of grade Ⅲ in men was associated with the risk of death from esophageal cancer with RRs of 1.21 (95% CI: 1.01 and 1.44) and 1.18 (95% CI: 1.00, 1.40) and 1.26 (95% CI: 1.06, 1.50). The female tooth loss grade Ⅱ, Ⅲ and esophageal cancer risk of death has nothing to do. Conclusion The risk of death from esophageal cancer may be increased in men with severe tooth loss, but female tooth loss may not be related to the survival of esophageal cancer.