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人和鼠胚胎肝脏均见高活性的γ—GT,而出生后则有迅速明显地降低。但在大鼠和小鼠化学诱发肝癌及其移植性肝癌的癌组织和带瘤鼠血清中γ—GT活性均明显增高。人肝癌患者血清中γ—GT亦常增高。所以γ—GT可作为肝癌的一种标志物。但有关小鼠自发性肝癌时血清γ—GT活性增高的报道尚不多见。
Both human and rat embryonic livers showed high activity of γ-GT, which rapidly and significantly decreased after birth. However, the activity of γ-GT in the serum of tumor-inducing mice and mice with chemically induced hepatocellular carcinoma and its transplanted hepatocellular carcinoma were significantly increased. The serum γ-GT in human liver cancer patients often increases. Therefore, γ-GT can be used as a marker of liver cancer. However, reports of increased serum γ-GT activity in mice with spontaneous hepatocellular carcinoma are rare.