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目的:探讨凝血因子Ⅰ(Fg)在不稳定型心绞痛(UA)发生、发展中的作用,以及与氧化应激的相关性。方法:冠心病(CHD)患者68例,包括稳定型心绞痛(SA)患者(SA组)20例,UA患者(UA组)48例,正常人(对照组)20例,分别测定血清Fg含量以及丙二醛(MDA)、超氧化物歧化酶(SOD)含量,同时分析Fg与MDA以及SOD之间的相关性。结果:UA组血清Fg含量均显著高于SA组和对照组(均P<0·01〉,而SA组患者与对照组相比差异无统计学意义(P>0·05)。CHD患者血清Fg水平与MDA水平呈明显正相关(P<0·01),而与SOD水平呈明显负相关(P<0·01)。结论:UA患者体内Fg含量明显升高,提示其病理机制与冠状动脉内血栓形成有关,而氧化应激可能是其主要影响因素之一。
Objective: To investigate the role of coagulation factor Ⅰ (Fg) in the development and progression of unstable angina pectoris (UA) and its relationship with oxidative stress. Methods: Sixty-eight patients with coronary heart disease (CHD) were enrolled in this study. They included 20 patients with stable angina pectoris (SA), 48 patients with UA (UA group) and 20 normal subjects (control group) Malondialdehyde (MDA) and superoxide dismutase (SOD), and the correlation between Fg, MDA and SOD was also analyzed. Results: The levels of serum Fg in UA group were significantly higher than those in SA group and control group (all P <0.01), but there was no significant difference between SA group and control group (P> 0.05) The level of Fg was positively correlated with MDA (P <0.01), but negatively correlated with the level of SOD (P <0.01) .Conclusion: The content of Fg in UA patients was significantly increased, suggesting that the pathological mechanism of coronary artery Arterial thrombosis, and oxidative stress may be one of the main influencing factors.