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目的观察大鼠腹部开放伤合并海水浸泡后不同时段病理学改变及电解质平衡的变化。方法成年健康Wistar大鼠116只,随机分为2组,其中腹部开放伤合并海水浸泡组为96只,腹部开放伤对照组为20只。在不同的时间点应用常规病理学和全自动生化检测仪对大鼠病理学改变及血浆K+、Na+、Cl-、Ca2+、Mg2+、Fe2+、渗透压水平进行检测,数据经SAS6.12统计软件分析处理。结果大鼠腹部开放伤合并海水浸泡后,心、肝、脾、肺、肾等脏器的病理变化与对照组相比更为严重;腹部开放伤合并海水浸泡组大鼠随着浸泡时间的延长,血浆中Cl-、Ca2+、Mg2+及渗透压明显增高。结论海水浸泡可造成腹部开放伤大鼠血浆渗透压及电解质变化,并引起多个重要脏器发生病理变化,这对明确腹部开放伤合并海水浸泡致伤的病理生理机制有着重要的意义。
Objective To observe the changes of pathological changes and electrolyte balance in open abdominal wounds and seawater immersion rats at different periods. Methods One hundred and sixty healthy adult Wistar rats were randomly divided into two groups, including 96 cases with open abdominal wound and seawater immersion group and 20 cases with open abdominal wound. Pathological changes and levels of K +, Na +, Cl-, Ca2 +, Mg2 +, Fe2 +, and osmotic pressure in rats were detected by routine pathology and automatic biochemical analyzer at different time points. The data were analyzed by SAS6.12 statistical software deal with. Results The pathological changes of heart, liver, spleen, lung, kidney and other organs were more serious in open abdominal wounds and seawater immersion rats. Compared with the control group, the pathological changes were more severe in rats with open abdominal wound and seawater immersion group as the soaking time , Plasma Cl-, Ca2 +, Mg2 + and osmotic pressure was significantly higher. Conclusions Seawater immersion can cause the changes of plasma osmotic pressure and electrolyte in open abdomen injured rats and lead to the pathological changes of many important organs. This is of great significance to clarify the pathophysiological mechanism of open abdomen injury and seawater immersion injury.