论文部分内容阅读
目的回顾性对比观察厄贝沙坦(angiotensin receptor blockers,ARB)与苯那普利(angiotensin convertion enzyme in-hibitors,ACEI)对轻、中度原发性高血压的疗效、不良反应。方法对比研究厄贝沙坦与苯那普利对128例轻、中度原发性高血压患者的降压疗效及药物不良反应。将研究对象随机分为两组,试验组和对照组分别口服厄贝沙坦每次150mg,1次/天,苯那普利10mg,1次/天。观察两组服药8周前后血压的改变,并于服药8周后行动态血压监测(ambulatory blood presure monitoring,AB-PM)。结果治疗8周后,两组患者血压均有下降,各项血压指标的比较值差异有统计学意义(P<0.01)。两组间ABPM结果显示,厄贝沙坦组血压负荷日间和晚间较苯那普利组差异有统计学意义(P<0.01)。两组降压的谷/峰(T/P)比值比较,厄贝沙坦组优于苯那普利组(P<0.05)。两药对心率均无明显影响。结论厄贝沙坦和苯那普利均能有效降低血压,ARB(厄贝沙坦)对DBP降幅高于ACEI(苯那普利)。
Objective To retrospectively compare the curative effects and adverse reactions of angiotensin receptor blockers (ARBs) and benazepril (angiotensin convertion enzyme in-hibitors) on mild to moderate essential hypertension. Methods A comparative study of irbesartan and benazepril in 128 patients with mild to moderate essential hypertension in antihypertensive efficacy and adverse drug reactions. The subjects were randomly divided into two groups, the experimental group and the control group were treated with irbesartan 150mg, 1 / day, benazepril 10mg, 1 / day. The changes of blood pressure before and after 8 weeks of treatment were observed. Ambulatory blood pressure monitoring (AB-PM) was performed 8 weeks after taking the medicine. Results After 8 weeks of treatment, the blood pressure of both groups decreased, and the comparison of various blood pressure indexes showed significant difference (P <0.01). ABPM results between the two groups showed that the blood pressure load in irbesartan group was significantly lower than that in benazepril group at daytime and nighttime (P <0.01). Compared with the benazepril group, the irbesartan group was better than the benazepril group (P <0.05). Two drugs have no significant effect on heart rate. Conclusion Both irbesartan and benazepril can effectively reduce blood pressure. The decline of DBP in ARB (irbesartan) is higher than that of ACEI (benazepril).