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目的:探讨成人牙周炎患者正畸治疗前后龈沟液中肿瘤坏死因子-α(TNF-α)含量变化和临床意义。方法:对38例成人牙周炎患者正畸治疗前后龈沟液TNF-α的动态监测,探讨TNF-α在临床治疗中的意义。结果:TNF-α在成人牙周炎患者龈沟液中含量显著高于无牙周炎患者,正畸治疗后TNF-α浓度显著减少(P<0.05);成人牙周炎患者正畸治疗后下前牙牙槽骨降低,后牙牙槽骨无明显改变。结论:TNF-α参与成人牙周炎患者正畸治疗中牙槽骨的改建,TNF-α是重要的炎性因子。
Objective: To investigate the changes and clinical significance of tumor necrosis factor-α (TNF-α) in gingival crevicular fluid before and after orthodontic treatment in adult periodontitis patients. Methods: Thirty-eight adult patients with periodontitis before and after orthodontic treatment of gingival crevicular fluid TNF-α dynamic monitoring of TNF-α in the clinical treatment of significance. Results: The content of TNF-α in gingival crevicular fluid of patients with adult periodontitis was significantly higher than that of patients without periodontitis, and the concentration of TNF-α was significantly decreased after orthodontic treatment (P <0.05). After the orthodontic treatment Lower anterior teeth alveolar bone, alveolar bone no significant change. Conclusion: TNF-α is involved in alveolar bone remodeling during orthodontic treatment in adult periodontitis. TNF-α is an important inflammatory factor.