用氧氟沙星、环丙沙星、诺氟沙星对从我院各种标本分享出的４１３株细菌作敏感试验，试验菌株有金葡球菌、克雷伯氏菌、大肠杆菌、绿脓假单胞菌等常见病原菌。药敏试验结果表明：这３种药物革兰氏阴性杆菌和部分革兰氏阳性球菌敏感率仍达７０％～９０％；甚至更高，但比以往文献报道的敏感率明显下降。本文提示要合理应用喹诺酮类药物，减少耐药菌株增加。 Using ofloxacin, ciprofloxacin, norfloxacin from various specimens of our hospital to share 413 strains of bacteria for sensitive tests, the test strains Staphylococcus aureus, Klebsiella, Escherichia coli, pus Pseudomonas and other common pathogens. The result of drug sensitivity test showed that the sensitivity of Gram-negative bacilli and some Gram-positive cocci of the three drugs still reached 70% -90%; even higher, but the sensitivity rate reported in the literature was obviously decreased. This article suggests that the rational use of quinolones to reduce drug-resistant strains increased.