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目的探讨利福平和利福喷丁血药峰值浓度监测预防肝损害的临床意义。方法对本科2 0 0 8年4月~2 0 1 3年4月1 0 6例化疗的肺结核患者,其中口服R F P患者6 0例,口服R F T患者4 6例。将R F P、R F T检测的情况分为5组:成年组、老年组、有肝炎病史组、营养不良组及酒精依赖组,测其峰值浓度进行比较。结果 R F P峰值浓度测定的分布,成年组峰值浓度测定分布大部分在正常范围。老年组、有肝炎病史组、营养不良组、酒精依赖组峰值浓度测定分布偏高。R F T峰值浓度测定的分布,成年组峰值浓度测定分布虽大部分在正常范围,但较R F P偏高。老年组、有肝炎病史组、营养不良组、酒精依赖组峰值浓度测定分布明显偏高。结论 R F P、R F T的峰值浓度测定方法简便,为临床剂量调整,预防肝损害具有一定指导意义。
Objective To investigate the clinical significance of rifampicin and rifapentine peak concentration monitoring in prevention of liver damage. Methods A total of 106 tuberculosis patients undergoing chemotherapy between April 2008 and April 2013 were enrolled in this study. Among them, 60 patients were orally given R F P, and 46 patients were given R F T orally. R F P, R F T detection of the situation is divided into 5 groups: adult group, elderly group, history of hepatitis group, malnutrition group and alcohol dependence group, measured peak concentrations were compared. Results The distribution of R F P peak concentration was measured and most of the distribution of peak concentration in adult group was in the normal range. Elderly group, with hepatitis history group, malnutrition group, peak concentration of alcohol dependence group distribution was high. The distribution of peak concentrations of R F T measured, although most of the distribution of peak concentration in adult group were in the normal range, but higher than that of R F P. Elderly group, with hepatitis history group, malnutrition group, alcohol dependence peak concentration distribution was significantly higher. Conclusion The method of determining the peak concentration of R F P and R F T is simple and convenient, which is of guiding significance for clinical dose adjustment and prevention of liver damage.