Liddle综合征(Liddle syndrome)又称遗传性假性醛固酮增多症,1964年由Liddle等首先报道,是以高血压、低血钾、低肾素活性、低醛固酮血症为特征的一种罕见的常染色体显性遗传疾病。我科在临床工作中遇到1例Liddle综合征,本报告旨在同大家共同探讨其遗传性、实验室检查、临床表现等,从而巩固及提高对本病的认知及诊治水平。患者,男,52岁,因“乏力2年”于2015年9月12日 Liddle syndrome (Liddle syndrome), also known as hereditary pseudoaldonosterism, first reported by Liddle et al in 1964, is a rare type of hypertension characterized by hypokalemia, hypokalemia, low renin activity and hypoaldosteronism Autosomal dominant genetic disease. Our department encountered 1 case of Liddle syndrome in clinical work. The purpose of this report is to discuss the hereditary, laboratory and clinical manifestations of the disease in order to consolidate and improve the cognition and diagnosis and treatment of this disease. Patient, male, 52 years old, due to “weakness 2 years ” on September 12, 2015