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目的:分析昆山市中医医院药品不良反应(ADR)病例的一般情况和特点,为临床用药提供参考和依据。方法:对2012年1—12月间上报于国家药品不良反应监测中心网络平台的225例ADR报告中相关因素进行统计与分析。结果:225例ADR报告的病例中,其年龄段在40~49岁和20~29岁之间发生ADR例数为最多,静脉给药(89.58%)是引发ADR主要给药途径,涉及14种类83种药品;抗感染药物导致ADR例数为最多(53.58%),其中头孢菌素的发生率为最高;其临床表现以皮肤及其附件损害为主(66.14%)。结论:加强对中青年患者的用药监测和静脉药物的用药监护,合理使用抗感染药物,严格中药注射剂的用药指征;加强ADR宣传和监测工作,保障临床用药安全。
Objective: To analyze the general situation and characteristics of adverse drug reaction (ADR) cases in Kunshan Hospital of Traditional Chinese Medicine, and to provide reference and basis for clinical medication. Methods: The data of 225 ADRs reported in the national ADR monitoring network platform from January to December in 2012 were analyzed. Results: Among the 225 cases of ADR, ADR cases were most frequently occurred between 40-49 years old and 20-29 years old. Intravenous administration (89.58%) was the main route leading to ADR and involved 14 kinds of ADR 83 kinds of drugs. Anti-infective drugs led to the highest number of ADR cases (53.58%), of which the highest incidence of cephalosporins; the clinical manifestations of damage to the skin and its accessories based (66.14%). Conclusion: To strengthen the monitoring of drug use in middle-aged and young patients and intravenous drug monitoring, rational use of anti-infective drugs, strict indications for the injection of Chinese medicine; strengthen ADR advocacy and monitoring to ensure the safety of clinical medication.