洛铂溶解在0.9%氯化钠或5%葡萄糖注射液中,采用高效液相色谱法分别测定在不同温度和浓度条件下,在上述2种注射液中24 h内的药物含量变化情况。结果表明,洛铂与0.9%氯化钠注射液配伍,25、37和42℃,在4 h内均稳定;与5%葡萄糖注射液配伍,25和37℃,在2 h内均稳定。此外还证实1与0.9%氯化钠或5%葡萄糖溶液配伍长时间后均可降解产生乳酸,且随时间延长而增加。 Lobacin dissolved in 0.9% sodium chloride or 5% glucose injection, the use of high performance liquid chromatography were measured at different temperatures and concentrations of the two kinds of injections within 24 h of drug content changes. The results showed that Losoplatin and 0.9% sodium chloride injection compatibility, 25,37 and 42 ℃, were stable within 4 h; compatibility with 5% glucose injection, 25 and 37 ℃, were stable within 2 h. In addition, it was also confirmed that 1 and 0.9% sodium chloride or 5% glucose solution can degrade lactic acid for a long time and increase with time.