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临床资料:6例NIDDM患者(男3,女3)为外院病人由急诊收入我院.年龄55～81岁.1例服用DBI已长达15年,1例仅5天,余4例在半年到3年.DBI每日剂量150mg 3例,75mg 2例,50mg 1例.其中4例单纯用DBI,1例合用优降糖,1例合用达美康.2例发病前1～2周无诱因开始出现乏力、恶心、呕吐、纳差及轻度腹泻、腹胀,但仍继续服用DBI;2例因饮食不当而引起急性胃肠炎,但未停用DBI;1例自行增加药量,从150mg至225mg,连服2天后出现酸中毒症状;1例一直未服降糖药,在院外使用DBI仅5天后即出现酸中毒症状,此例患者入院前4年尿素氮(BUN)8.9mmol/L,入院时,BUN为16mmol/L.1例(死亡例)入院前1年尿蛋白持续-～--,但在院外一直口服DBI,因出现水肿、尿
Clinical data: 6 cases of NIDDM patients (male 3, female 3) were hospitalized by emergency department in our hospital, aged from 55 to 81. One patient had been taking DBI for 15 years, one patient had only 5 days, and the remaining 4 patients were in half a year To 3 years.DBI daily dose of 150mg in 3 cases, 75mg 2 cases, 50mg in 1 case.Among them 4 cases of simple DBI, 1 cases of combined oral administration of glyburide, 1 case of combination of metmymethae 2. 2 cases before the onset of 1 to 2 weeks Incentives began to appear fatigue, nausea, vomiting, anorexia and mild diarrhea, bloating, but still taking DBI; 2 cases of acute gastroenteritis caused by improper diet, but did not disable DBI; 1 case of self-medication to increase the dose from 150mg to 225mg, even after 2 days of symptoms of acidosis; 1 case has not been taking hypoglycemic agents, only 5 days after the use of DBI in hospital appeared acidosis symptoms, this patient 4 years before admission urea nitrogen (BUN) 8.9mmol / L, admission BUN 16mmol / L in 1 case (death cases) 1 year before admission urinary protein continued - ~ -, but outside the hospital has been oral DBI, due to edema, urine