心肌肥大是高血压病重要的合并症,也是心力衰竭的前期病变。探讨心肌肥大的发展机制、寻求合理的防治措施一直是该领域的重大研究课题。目前对引起心肌肥大反应的刺激信号及其信号转导通路已有了比较深入的了解,以一氧化氮为代表的内源性扩血管物质对心肌肥大的影响也引起了人们的关注,本文就近期该方面的研究作一综述。 Cardiac hypertrophy is an important complication of hypertension, is also a pre-heart disease heart failure. To explore the mechanism of myocardial hypertrophy and to seek a reasonable prevention and control measures has been a major research topic in this field. At present, there is a deep understanding of the stimulatory signal and its signal transduction pathway that causes cardiac hypertrophy response. The effect of endogenous vasodilator represented by nitric oxide on cardiac hypertrophy has aroused people’s attention. Recent research in this area is reviewed.