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40年前,Von Euler 发现吸入低氧气体可直接作用于肺血管使之收缩,从而引起肺动脉压力(P_(PA))升高。其工作为肺循环调节的研究揭开了新的一页。但慢性缺氧性肺动脉高压并非简单的急性缺氧过程的延长,还伴随着更明显的全身变化。许多作者已经注意到,颈动脉体作为主要的缺氧化学感受器,与肺循环之间存在着密切关系。本文着重介绍该化学感受器在慢性缺氧性肺动脉高压中的作用。【颈动脉体化学感受器功能降低与肺动脉压
40 years ago, Von Euler found that inhalation of hypoxia gas can act directly on the pulmonary vasoconstriction to cause pulmonary artery pressure (P_ (PA)) increased. His work opened a new chapter in the study of pulmonary regulation. However, chronic hypoxic pulmonary hypertension is not a simple extension of acute hypoxia, but also accompanied by more pronounced systemic changes. Many authors have noticed that the carotid body as a major hypoxic chemoreceptor has a close relationship with pulmonary circulation. This article focuses on the role of chemokines in chronic hypoxic pulmonary hypertension. Carotid Body Chemoreceptor Function Reduction and Pulmonary Artery Pressure