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目的:探讨中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)及系统免疫炎症指数(SII)在肝癌根治术患者中的表达及与预后的相关性。方法:回顾性选择2016年3月至2018年1月本院收治的肝癌根治术患者78例作为对象，设为观察组；所有患者均拟行肝癌根治术治疗。选择同期治疗的肝脏良性疾病手术患者58例，设为对照组。采用全自动生化分析仪完成患者中性粒细胞、淋巴细胞、血小板水平，计算NLR、PLR值；利用公式血小板×中性粒细胞/淋巴细胞计算SII；记录患者性别、年龄、术前ALT、肿瘤直径、术前甲胎蛋白(AFP)、肝功能分级等指标，并对观察组患者NLR、PLR和SII的影响因素进行多因素logistic分析；患者治疗后进行18个月随访，根据预后分为死亡组与存活组，记录两组患者NLR、PLR、SII水平，并分析其与预后的相关性。结果:观察组原发性肝癌患者NLR(7.48±1.21)、PLR(25.31±4.23)、SII(452.98±43.69)，均高于对照组NLR(2.35±0.96)、PLR(10.49±2.44)、SII(253.23±25.31)(n t＝6.391、5.328、8.562，n P<0.05)；观察组NLR、PLR、SII水平与术前ALT、肿瘤直径、术前AFP、肝功能分级有关(n P<0.05)；原发性肝癌患者随访18个月，存活患者55例，死亡23例。存活组原发性肝癌患者NLR(4.39±1.46)、PLR(15.93±4.39)、SII(275.69±21.53)，低于死亡组NLR(13.59±2.49)、PLR(53.29±6.41)、SII(574.67±46.39)(n t＝7.398、4.395、6.781，n P<0.05)。Pearson相关性分析结果表明：原发性肝癌患者NLR、PLR、SII水平与患者治疗预后呈负相关(n r＝-0.693、-0.771、-0.709，n P<0.05)。n 结论:NLR、PLR、SII在肝癌根治术患者呈高表达，其表达水平与患者预后存在相关性，监测其表达水平能评估预后，指导临床治疗。“,”Objective:To investigate the correlation between the expression of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and systemic immunoinflammatory index (SII) in patients with radical hepatectomy.Methods:A total of 78 patients with radical hepatectomy from March 2016 to January 2018 were enrolled in the observation group. All patients were treated with radical hepatectomy. 58 patients with liver benign disease treated at the same time were selected as the control group. The patient′s neutrophil, lymphocyte and platelet levels were calculated by automatic biochemical analyzer, and the NLR and PLR values were calculated. The SII was calculated using the formula platelet × neutrophil/lymphocyte; The patients′ gender, age, preoperative alanine aminotransferase (ALT), tumor diameter, preoperative alpha-fetoprotein (AFP), liver function classification and other indicators were recorded, and univariate and multivariate logistic analysis was performed; the patients were followed up for 18 months after treatment, and were divided into death group and survival group according to the prognosis. The levels of NLR, PLR and SII in the two groups were recorded and analyzed. Pearson correlation analysis was used to analyze the correlation between NLR, PLR, SII and prognosis.Results:The levels of NLR (7.48±1.21), PLR (25.31±4.23) and SII (452.98±43.69) in the observation group were higher than those in the control group [NLR(2.35±0.96), PLR (10.49±2.44) and SII (253.23±25.31)] (n t=6.391, 5.328, 8.562, n P<0.05). The results of univariate and multivariate logistic analysis showed that the levels of NLR, PLR and SII in the observation group were related to preoperative ALT, tumor diameter, preoperative AFP and liver function classification (n P<0.05); 55 patients survived and 23 died in 18 months follow-up. The levels of NLR (4.39±1.46), PLR (15.93±4.39) and SII (275.69±21.53) in survival group were lower than those in death group [NLR (13.59±2.49), PLR (53.29±6.41), SII (574.67±46.39)] (n t=7.398, 4.395, 6.781, n P<0.05). The results of Pearson correlation analysis showed that the levels of NLR, PLR and SII were negatively correlated with the prognosis of patients (n r=-0.693, -0.771, -0.709, n P<0.05).n Conclusions:NLR, PLR and SII are highly expressed in patients with radical hepatectomy. The expression level of NLR, PLR and SII is correlated with the prognosis of patients, monitoring their expression level can evaluate the prognosis and guide clinical treatment.