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7603为一种新络合剂,化学名为5-甲基亚胺 N.N 二乙酸香草醛(MIDAV)。肌注2mM、kg7603对大鼠体内放射性钍有较好的促排效果。可使尿、粪中~(234)Th 总排出量比对照组高5—7倍,肝、骨中蓄积量分别为对照组的6%和35%。对肝钍的促排优于811。7603对~(234)Th 的促排特点是粪~(234)Th 排出量高于尿~(234)Th 排出量。在实验剂量范围50—800mg/kg内,7603的疗效随剂量的增加而提高。延缓给药时效果下降;核素注入前1小时给药与注入核素后立即给药疗效相同。中毒1小时后给药,增加用药次数能提高促排效果。7603对~(144)Ce 也有较好的促排作用,但不及 DTPA 好。
7603 is a new complexing agent chemically named 5-methylimine N. N diacetate vanillin (MIDAV). Intramuscular injection of 2mM, kg7603 on the body of radioactive thorium in rats have a better effect of promoting emission. Total excretion of ~ (234) Th in urine and feces was 5-7 times higher than that in the control group, and liver and bone contents were 6% and 35% of those in the control group respectively. The promotion of liver thorium is better than that of 811.7603 to 234 234 Th is that the excretion of fecal 234 234 Th is higher than the urinary 234 ex Th. In the experimental dose range of 50-800mg / kg, the efficacy of 7603 increased with increasing dose. Delayed administration of the effect decreased; 1 hour before the injection of nuclide administration and nuclide injection immediately after treatment with the same effect. Poison 1 hour after administration, increase the frequency of medication can increase the effect of promoting emissions. 7603 ~ ~ (144) Ce also has a good role in promoting the emission, but not as good as DTPA.