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目的探讨甲泼尼龙联合丙种球蛋白对病毒性脑炎患儿心理状况和预后的影响。方法将我院于2013年1月至2015年5月期间收治的94例病毒性脑炎患儿,随机分成实验组和对照组,每组47例。对照组使用阿昔洛韦及地塞米松常规等治疗,治疗组在常规治疗的基础上静脉增用甲泼尼龙和丙种球蛋白。使用父母用症状问卷(PSQ)、运动功能评分(FMA)和痉挛量表(ASS)评估两组患者治疗前后的心理及运动功能障碍,同时调查患者的不良反应。结果两组患者在治疗前的PSQ、FMA和ASS评分,组间对比差异不明显(P>0.05)。治疗后,实验组患者各项PSQ评分明显低于对照组(P<0.01),实验组和对照组的总有效率分别为91.11%、73.33%,差异有统计学意义(P<0.01),两组之间的不良反应发生率无统计学差异(P>0.05)。结论甲泼尼龙联合丙种球蛋白治疗有助于改善病毒性脑炎患儿的心理状况,且可行性、安全性良好。
Objective To investigate the effect of methylprednisolone combined with gamma globulin on the psychological status and prognosis of children with viral encephalitis. Methods 94 cases of viral encephalitis admitted to our hospital from January 2013 to May 2015 were randomly divided into experimental group and control group, with 47 cases in each group. The control group was treated with acyclovir and dexamethasone routinely. The treatment group received intravenous methylprednisolone and gamma globulin on the basis of routine treatment. The PSQ, FMA and ASS were used to evaluate the psychological and motor dysfunction in both groups before and after treatment, and the adverse reactions of the patients were also investigated. Results Before treatment, PSQ, FMA and ASS scores of two groups were not significantly different (P> 0.05). After treatment, the PSQ scores in the experimental group were significantly lower than those in the control group (P <0.01). The total effective rates in the experimental group and the control group were 91.11% and 73.33%, respectively, with significant differences (P <0.01) The incidence of adverse reactions between the two groups showed no significant difference (P> 0.05). Conclusion The combination of methylprednisolone and gamma globulin can improve the psychological status of children with viral encephalitis, and its feasibility and safety are good.