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作者随机选择分泌性中耳炎（ Ｏ Ｍ Ｅ）患者４０例为观察组，另选择健康成人及儿童４０例为对照组。用分光光度计法定量测定正常人及 Ｏ Ｍ Ｅ患者鼻咽部灌洗液中代表表面活性物质的卵磷脂含量，间接反映其表面活性物质的量，以探讨 Ｏ Ｍ Ｅ的发病机理和新的治疗方法。结果显示， Ｏ Ｍ Ｅ患者鼻咽部灌洗液中卵磷脂含量为８６３７±２．７３０ｍ ｇ／ Ｌ，较正常对照组３９．２１２±２．４３７ｍ ｇ／ Ｌ 明显减少（ Ｐ＜ ０．０１ ），儿童患者其卵磷脂含量为８．０６２±２９２５ｍ ｇ／ Ｌ较正常同龄对照组３９．７８７±２．５５７ｍ ｇ／ Ｌ显著减少（ Ｐ＜ ０．０１ ），表面活性物质含量与病程无明显相关。以上提示：局部表面活性物质减少可能是 Ｏ Ｍ Ｅ发病机理之一，外源性表面活性物质的应用和促进内源性表面活性物质的分泌可能为预防和治疗 Ｏ Ｍ Ｅ提供一条新途径。
The authors randomly selected 40 patients with secretory otitis media (O M E) as the observation group and another 40 healthy adults and children as the control group. Quantitative determination of lecithin in the nasopharyngeal lavage fluid of normal subjects and O M E patients by spectrophotometer method indirectly reflect the amount of surfactant and explore the pathogenesis of O M E and new treatment method. The results showed that the content of lecithin in nasopharyngeal lavage of O M E patients was 8637 ± 2.730 m g / L, which was significantly lower than that of the normal control group (39.212 ± 2.437 m g / L, P <0. 01), children with lecithin content of 8.062 ± 2. 925m g / L compared with the normal age control group 39.787 ± 2.557m g / L significantly reduced (P <0.01), the content of surfactant and No significant correlation between the course of the disease. The above suggests that the reduction of topical surfactant may be one of the pathogenesis of O M E. The application of exogenous surfactant and the promotion of secretion of endogenous surfactant may provide a new way to prevent and treat O M E.