论文部分内容阅读
目的:探讨替罗非班联合小剂量肝素治疗进展性脑卒中合并颅内、外血管狭窄的临床疗效。方法:将128例进展性脑卒中合并颅内、外血管狭窄患者按随机数字表法分为观察组和对照组各64例,对照组患者单用肝素进行治疗,观察组患者联合应用小剂量肝素和替罗非班。结果:治疗后,观察组患者1 d、2 d、3 d、1周的神经功能缺损评分均显著低于对照组,差异有统计学意义(P<0.05);观察组患者的预后改善率,血管轻、中度狭窄率均显著高于对照组,差异有统计学意义(P<0.05);观察组患者的动脉狭窄改善时间为(3.62±1.23)d,明显短于对照组的(5.85±2.11)d,差异有统计学意义(P<0.05);观察组患者再梗及卒中发生率为3.13%,明显低于对照组的9.38%,差异有统计学意义(P<0.05)。结论:对进展性脑卒中合并颅内、外血管狭窄患者联合应用替罗非班和小剂量肝素进行治疗,可有效改善神经功能缺损情况,改善预后,值得推广。
Objective: To investigate the clinical efficacy of tirofiban combined with low-dose heparin in treatment of patients with progressive stroke complicated with intracranial and extravascular stenosis. Methods: 128 cases of progressive stroke with intracranial and extracranial vascular stenosis were randomly divided into observation group and control group, 64 cases in each group. Patients in control group were treated with heparin alone. Patients in observation group were treated with low dose heparin And tirofiban. Results: After treatment, the scores of neurological deficit in observation group at 1, 2, 3 and 1 week were significantly lower than those in control group (P <0.05); the improvement rate of prognosis in observation group, The vessel stenosis rate was significantly higher than that of the control group (P <0.05). The improvement time of stenosis was (3.62 ± 1.23) d in the observation group, which was significantly shorter than that in the control group (5.85 ± 2.11) d, the difference was statistically significant (P <0.05). The incidence of reinfarction and stroke in the observation group was 3.13%, which was significantly lower than that in the control group (9.38%, P <0.05). Conclusion: The combination of tirofiban and low-dose heparin in patients with progressive stroke complicated with intracranial and extravascular stenosis can effectively improve the neurological deficit and improve the prognosis, which is worthy of popularization.