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目的探讨尿毒症患者血液透析 ( HD)前后血胰岛素样生长因子 -1( IGF-1)水平变化规律及意义。方法对 3 0例尿毒症患者 HD前、后的血清 IGF-1、尿素氮 ( BUN)、肌酐 ( Cr)、钙 ( Ca)、磷 ( P)等指标进行比较 ,并与正常对照组 ( 15例 )进行比较。结果尿毒症患者HD前后血清 IGF-1水平 [( 1.2 9± 0 .83 ) ng/ml、( 1.5 6± 0 .63 ) ng/ml]显著低于正常对照组 ( 2 .67± 1.71) ng/ml( P<0 .0 1) ,而 HD后水平显著高于 HD前水平 ( P<0 .0 5 )。 HD前 IGF -1水平与 BUN、Scr、Ca、P无显著相关性 ( P>0 .0 5 )。结论 HD可一过性提高尿毒症患者血清 IGF-1水平 ,在某种程度上有助于改善患者的营养不良 ,但作用不持久 ,其临床意义有待进一步探讨。
Objective To investigate the changes and significance of insulin-like growth factor-1 (IGF-1) level in hemodialysis patients before and after hemodialysis (HD). Methods The serum levels of IGF-1, BUN, Cr, Ca and P before and after HD in 30 patients with uremia were compared with those of control group (15 Example) for comparison. Results Serum levels of IGF-1 in serum of patients with uremia before and after HD were significantly lower than those of the control group [(1.2 9 ± 0.83) ng / ml, (1.5 6 ± 0.63) ng / ml] / ml (P <0.01), while the post-HD level was significantly higher than the pre-HD level (P <0.05). The level of IGF-1 before HD was not significantly correlated with BUN, Scr, Ca, P (P> 0.05). Conclusions HD can improve serum IGF-1 level in patients with uremia transiently and help to improve malnutrition to a certain extent. However, its effect is not lasting. Its clinical significance remains to be further explored.