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为探讨肿瘤坏死因子α(TNFα)在急性白血病骨髓完全缓解和非完全缓解状态下的临床意义,采用放免法测定血清中TNFα水平。结果显示:急性白血病患者TNFα为563±191fmol/ml,其中完全缓解者为414±152foml/ml,非完全缓解者为613±179fmol/ml,均明显高于对照组232±090fmol/ml,完全缓解者与非完全缓解者比较差异有高度显著性(P<0001)。提示TNFα与急性白血病病情有关。
In order to investigate the clinical significance of tumor necrosis factor α (TNFα) in complete remission and incomplete remission of acute leukemia, serum TNFα levels were determined by radioimmunoassay. The results showed that: TNFα in patients with acute leukemia was 5 63 ± 1 91fmol / ml, complete remission was 4 14 ± 1 52foml / ml, those with incomplete remission was 6 13 ± 1 79fmol / ml, were significantly Higher than the control group 2 32 ± 0 90fmol / ml, complete remission and non-complete remission were significantly higher (P <0001). Tip TNFα and acute leukemia disease.