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从华中五味子提取的有效部分中分得六种结晶成分,其一鉴定为去氧五味子素(Ⅷ),其余五种为新化合物,命名为五味子酯甲、乙、丙、丁和戊.它们的结构式及构象经光谱及化学降解分别确定为Ⅰ_a,Ⅱ_b;Ⅱ_a,Ⅱ_b;Ⅲ_a,Ⅲ_b;Ⅳ_a,Ⅳ_b;Ⅴ_a,Ⅴ_b所示.其联苯及C_6,C_7,C_8的绝对构型皆为(S)型.并将前人从北五味子中分得的γ-五味子素和五味子丙素结构中的次甲二氧基位置,改正为Ⅵ,Ⅶ所示.药理试验及初步临床观察表明:酯甲、乙、丙和丁对迁延性、慢性病毒性肝炎患者有较好的降血清谷丙转氨酶的作用.酯戊及去氧五味子素无效。
Five kinds of crystal components were isolated from the active fractions extracted from Schisandra chinensis, one of them was identified as deoxyschizandrin (Ⅷ) and the other five were new compounds, named Schisandra chinensis A, B, C, D and E. Their The structures and conformations were identified as Ⅰ_a, Ⅱ_b, Ⅱ_a, Ⅱ_b, Ⅲ_a, Ⅲ_b, Ⅳ_a, Ⅳ_b, Ⅴa, and Ⅴ_b by the spectral and chemical degradation respectively.The absolute configurations of biphenyl and C_6, C_7 and C_8 were all (S ) Type and the former from the North Schisandra in the division of γ-Schisandrin and Schisandrin C structure methyldioxy position, corrected to Ⅵ, Ⅶ shown in Pharmacological tests and preliminary clinical observations showed that: ester A , B, C and D in patients with persistent, chronic viral hepatitis has a better serum alanine aminotransferase role. Ester and deoxygermin on invalid.