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近年发现自然杀伤(NK)细胞及杀伤细胞免疫球蛋白样受体(KIR)能识别HLA-I类分子,传导激活或抑制信号,从而调节NK细胞和T细胞的活性,在血液干细胞移植与移植物抗宿主病等中发挥重要的作用。现综述NK细胞和KIR的作用、KIR基因多态性及有关肾移植的研究进展。
In recent years, natural killer (NK) cells and killer cell immunoglobulin-like receptors (KIRs) have been shown to recognize HLA-I molecules and activate or inhibit signaling to regulate the activity of NK cells and T cells. In blood stem cell transplantation and transplantation Anti-host disease play an important role. Are summarized in the role of NK cells and KIR, KIR gene polymorphism and renal transplantation research progress.