Objective:To investigate the hepatoprotective activity of methanolic extract of leaves of Erythroxylum monogynum(E.monogynum)on paracetamol induced toxicity.Methods:Methanolic extract of leaves of E.monogynum was given in doses of 100 mg/kg,200 mg/kg and 400 mg/kg for 7 d and toxicity was induced by paracetamol(2 mg/kg)on Day 8.Silymarin(50 mg/kg)was used as reference standard.After 24 h of toxicity induction blood samples were collected from retro-orbital plexsus and analyzed for serum parameters like serum glutamic pyruvic transaminase,serum glutamic oxaloacetate transaminse,alkaline phosphatase and total bilirubin.Livers isolated were studied for histopathological changes.Results:Phytochemical analysis of methanolic extract of E.monogynum leaves showed the presence of carbohydrates,flavonoids,phenols and saponins.Prior administration of this extract restored the elevated levels serum markers as compared to toxic group which is also confirmed by the histopathological changes observed.Conclusions:The present study showed that methanolic extract of leaves of E.monogynum possess hepatoprotective action against paracetamol induced hepatotoxicity. Objective: To investigate the hepatoprotective activity of methanolic extract of leaves of Erythroxylum monogynum (E. monogynum) on paracetamol induced toxicity. Methods: Methanolic extract of leaves of E. monogynum was given in doses of 100 mg / kg, 200 mg / kg and 400 mg / kg for 7 days and toxicity was induced by paracetamol (2 mg / kg) on ​​Day 8. Silymarin (50 mg / kg) was used as a reference standard. After 24 h of toxicity induction blood samples were collected from retro- orbital plexsus and analyzed for serum parameters like serum glutamic pyruvic transaminase, serum glutamic oxaloacetate transaminse, alkaline phosphatase and total bilirubin. Livers isolated were studied for histopathological changes. Results: Phytochemical analysis of methanolic extract of E. monogynum leaves showed the presence of carbohydrates, flavonoids , phenols and saponins. Prior administration of this extract restored the elevated levels serum markers as compared to toxic group which is also confirmed by the histopathological changes observed .Conclusions: The present study showed that methanolic extract of leaves of E.monogynum possess hepatoprotective action against paracetamol induced hepatotoxicity.