经历了200余年之后,洋地黄作为充血性心衰强心治疗的主角地位正在受到挑战。髓袢利尿剂针对钠水潴留;血管扩张剂降低心脏负荷均有一定裨益。心脏β受体兴奋剂的正性肌力作用强大,亦制成口服品种,但可增加心率、自律性和氧耗,且易发生耐受而减敏。茶碱和胰高血糖素的强心效力不高,仅作为辅助治疗。当前的注意力集中于磷酸二酯酶组份Ⅲ选择性抑制剂(氨吡酮、甲腈吡酮等)和腺苷酸环化酶激活剂(佛司可林)上面。 After more than 200 years, digitalis is being challenged as the protagonist of congestive heart failure. Nectar loop diuretics for sodium and water retention; vasodilators reduce heart load have some benefits. Cardiac β receptor agonist positive inotropic effect, but also made of oral varieties, but can increase heart rate, self-discipline and oxygen consumption, and prone to tolerance and desensitization. Cardiac and glucagon cardiac function is not high, only as adjuvant therapy. Current attention has focused on the selective inhibitors of phosphodiesterase III (eg, pyritone, tetracamide, etc.) and adenylyl cyclase activators (forskolin).