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本文应用反相HPLC建立了阿糖腺苷毫微囊(Ara-A-NC)混悬型注射剂中Ara-A的含量测定方法,并以此法研究了Ara-A-NC的化学稳定性。结果表明,Ara-A-NC注射剂中Ara-A受热作用,按一级动力学降解,降解反应的活化能为46.49kJ/mol,初步预测Ara-A-NC有效期为10.47个月(25℃).
In this paper, Ara-A-NC suspension was used to establish a method for the determination of Ara-A in Ara-A-NC injection. The chemical stability of Ara-A-NC was studied by reverse phase HPLC. The results showed that Ara-A was injected into Ara-A injection and was degraded by first-order kinetics. The activation energy of Ara-A-NC injection was 46.49 kJ / mol and the Ara-A-NC was 10.47 months .