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骨保护素(OPG)作为肿瘤坏死因子受体超家族成员,不仅是骨代谢的一个重要调节因子,还是重要的血管调节因子,能够保护血管内皮细胞,抑制血管钙化和动脉粥样硬化。冠状动脉粥样硬化性心脏病(冠心病)及外周动脉硬化疾病血清OPG水平及动脉壁中OPG含量明显升高,OPG在动脉粥样硬化的发生发展中可能起着重要的调节作用。但其确切的机制尚不清楚,可能是一种自我防御代偿机制,以对抗促动脉粥样硬化、血管钙化及血管损伤的其它因子。
Osteoprotegerin (OPG), a member of tumor necrosis factor receptor superfamily, is not only an important regulator of bone metabolism, but also an important angiogenic factor that protects vascular endothelial cells and inhibits vascular calcification and atherosclerosis. In patients with coronary atherosclerotic heart disease (CHD) and peripheral arteriosclerosis, serum OPG level and OPG content in arterial wall are significantly increased. OPG may play an important regulatory role in the development of atherosclerosis. However, its exact mechanism is unclear and may be a self-defense compensatory mechanism to combat other factors that promote atherosclerosis, vascular calcification, and vascular injury.