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目的 观察大鼠持续局灶性脑缺血模型一氧化氮作用规律，同时或分别应用一氧化氮合成前体物质──左旋精氨酸和一氧化氮合成酶抑制剂──氨基胍治疗大鼠局灶性脑缺血。方法通过生化、脑梗死体积测定、超微结构观察手段，观察左旋精氨酸及一氧化氮合成酶抑制剂对缺血３０分钟、６０分钟、１２０分钟、１８０分钟大鼠脑组织的作用。结果 缺血３０分钟单用左旋精氨酸大鼠脑组织损伤最轻，而两者合用略重于前者，缺血６０分钟、１２０分钟、１８０分钟两者合用损伤最轻。结论左旋精氨酸与肌氨酸合用是治疗大鼠局灶性脑缺血理想、可行的方案。
OBJECTIVE: To observe the regularity of nitric oxide (NO) activity in rats with persistent focal cerebral ischemia and to observe the effects of nitric oxide synthesis precursor (L-arginine and nitric oxide synthase inhibitor) Focal cerebral ischemia. Methods The effects of L-arginine and nitric oxide synthase inhibitor on the brain tissue of rats at 30, 60, 120 and 180 minutes after ischemia were observed through biochemical and cerebral infarction volume measurement and ultrastructure observation. Results The brain tissue of rats with L-arginine was the lightest at 30 minutes of ischemia, while the combined use of L-arginine and L-arginine was the heaviest. The ischemia was 60 minutes, 120 minutes and 180 minutes respectively. Conclusion The combination of L-arginine and creatine is an ideal and feasible solution for focal cerebral ischemia in rats.