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目的 探讨女性急性脑梗死（ＡＣＩ）患者血清性激素水平的变化及其对血脂的影响。方法应用酶联免疫吸附法、酶比色法和直接测定法检测女性ＡＣＩ患者的血清雌二醇（Ｅ２）、睪酮（Ｔｅ）、Ｅ２／Ｔｅ及血脂含量并与健康人比较。结果 女性ＡＣＩ患者有性激素失衡及血脂异常，Ｅ２、Ｔｅ、ＨＤＬ含量降低，以Ｅ２降低更为明显（Ｐ＜０．０１、Ｐ＜０．０５、Ｐ＜０．０５），而Ｅ２／Ｔｅ无显著性差异（Ｐ＞０．０５），ＬＤＬ、ＴＣ含量较对照组明显升高，均有显著性差异（Ｐ＜０．０１）。结论 性激素水平紊乱是女性急性脑梗死患者的危险因素之一，并影响脂质代谢。
Objective To investigate the changes of serum sex hormone levels in female patients with acute cerebral infarction (ACI) and their effects on blood lipids. Methods Serum estradiol (E2), tetrone (Te), E2 / Te and blood lipids were detected by enzyme-linked immunosorbent assay, enzyme colorimetry and direct assay in female ACI patients and compared with healthy volunteers. Results The female patients with ACI had sex hormone imbalance and dyslipidemia, the contents of E2, Te and HDL decreased, and the E2 decreased more obviously (P <0.01, P <0.05, P <0.05) Significant difference (P> 0.05), LDL, TC content was significantly higher than the control group, were significantly different (P <0.01). Conclusion Disorder of sex hormones is one of the risk factors of female patients with acute cerebral infarction and affects lipid metabolism.