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目的：观察较长期（６ｍｏ）服用比索洛尔治疗冠心病病人的左室舒张功能不全的疗效。方法：用彩色多普勒超声心动图和放射核素门控心血池显像联合评定左室舒张功能。冠心病伴左室舒张功能不全病人２５例（男性１７例，女性８例。年龄５４±ｓ１２ａ）予硝酸异山梨酯５～１０ｍｇ，ｐｏ，ｔｉｄ×（２～４）ｗｋ；泛癸利酮５～１０ｍｇ，ｐｏ，ｔｉｄ×６ｍｏ为基础，加服比索洛尔２．５～５ｍｇ，ｐｏ，ｑｄ×６ｍｏ。并与２５例健康者比较。结果：左室舒张功能如早期充盈峰速度（Ｅ波）、Ｅ波减速度和左室峰充盈率均非常显著增加（Ｐ＜０．０１）；晚期充盈峰速度（Ａ波）、Ａ／Ｅ比率和Ｅ波减速时间则明显降低（Ｐ＜０．０５）。结论：加用比索洛尔６ｍｏ能显著改善冠心病病人左室舒张功能。
Objective: To observe the long-term (6mo) taking bisoprolol in patients with coronary heart disease in patients with left ventricular diastolic dysfunction. Methods: The left ventricular diastolic function was assessed by color Doppler echocardiography and radionuclide gated cardiac pool imaging. Coronary heart disease with left ventricular diastolic dysfunction in 25 patients (17 males and 8 females, age 54 ± s12a) isosorbide mononitrate 5 ~ 10mg, po, tid × (2 ~ 4) wk; ~ 10mg, po, tid × 6mo basis, plus bisoprolol 2.5 ~ 5mg, po, qd × 6mo. And compared with 25 healthy subjects. Results: Left ventricular diastolic function such as early filling peak velocity (E wave), E wave deceleration and left ventricular peak filling rate were significantly increased (P <0.01); late filling peak velocity (A wave), A / E Ratio and E wave deceleration time was significantly reduced (P <0.05). Conclusion: Bisoprolol 6mo can significantly improve left ventricular diastolic function in patients with coronary heart disease.