论文部分内容阅读
抗结核药物问世前,结核病对孕妇及胎儿的有害形响是很清楚的。随着现代化学疗法的问世,预后已有明显改善。但妊娠期使用抗结核药物又出现了新问题,其一是可能发生胎儿畸形,因此有些医生主张人工流产。作者调查了妊娠期使用过INH、RFP和EB等药物的14名患活动性肺结核的孕妇,在妊娠期间、分娩时或终止妊振后头一个月内均未发现并发症。11名活产儿童(分娩4天至7岁)也未发现异常现象,其他3名做了人工流产。同时,作者对患结核病的孕妇曾于妊娠期间使用过INH、SM、EB和/或RFP治疗的大量资料进行了复习,并对其妊娠后果加以讨论。1302名使用INH病人中胎儿或婴儿异常有16例;203名使用SM者中正常婴儿170名,异常35例且多为听神经
Before the advent of anti-TB drugs, tuberculosis on pregnant women and fetuses detrimental is very clear. With the advent of modern chemotherapy, the prognosis has been significantly improved. However, there are new problems arising from the use of anti-tuberculosis drugs during pregnancy. One of them is the possible fetal malformation. Therefore, some doctors advocate abortion. The authors investigated 14 pregnant women with active tuberculosis who had used INH, RFP and EB and other drugs during pregnancy. No complications were found during pregnancy, during labor or within the first month after termination of pregnancy. Eleven live births (childbirth from 4 days to 7 years old) also found no abnormalities and the other 3 had abortions. In the meantime, the authors reviewed extensive information on the use of INH, SM, EB and / or RFP during pregnancy in pregnant women with tuberculosis and discussed their pregnancy outcomes. Of the 1302 infants or infants with INH, there were 16 abnormal fetuses or infants; 170 of the 203 infants with SM were normal, and 35 were abnormal and mostly were auditory nerves