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目的:探讨在肺移植手术麻醉中CVP、舒张末期容积指数（global end-diastolic volume index, GEDI）、胸腔血容积指数（intrathoracic blood volume index, ITBI）与心脏指数（cardiac index, CI）的相关性，为临床应用提供参考。方法:选择行肺移植手术的终末期肺病患者22例，麻醉诱导完成后于左侧股动脉穿刺置入脉搏指示连续心排血量（pulse index continuous cardiac output, PiCCO）专用带温度探头的压力监测管并连接监护仪，右颈内静脉或锁骨下静脉穿刺放置中心静脉导管监测CVP，同时右侧颈内静脉放置连续温度稀释Swan-Ganz导管，连续监测肺动脉压（pulmonary arterial pressure, PAP）、CI、GEDI及ITBI。分别记录麻醉后5 min双肺通气时（Tn 0）、手术开始后20 min单肺通气时（Tn 1）、肺动脉阻断10 min时（Tn 2）、肺动脉开放后20 min时（Tn 3）、恢复双肺通气20 min后（Tn 4）和手术结束平卧位10 min后（Tn 5）的MAP、心率、PAP、CVP、CI、GEDI及ITBI。对CVP、GEDI、ITBI与CI行相关性分析。n 结果:各时间点的MAP和心率差异无统计学意义（n P>0.05）；与Tn 0时点比较，Tn 3、Tn 4、Tn 5时点PAP明显降低（n P<0.05），Tn 2时点PAP明显高于其他各时点（n P<0.05）；Tn 1、Tn 2时点CVP明显高于其他时点（n P<0.05）；Tn 2时点CI与其他时间点比较明显降低（n P<0.05）；Tn 2时点GEDI及ITBL较Tn 0、Tn 3明显降低（n P0.05）；Tn 0、Tn 4及Tn 5时点，CVP与CI呈正相关（n P<0.05）；Tn 0~Tn 5时点，GEDI、ITBI与CI呈正相关（n P0.05). Compared with those at Tn 0, remarkable decreases were found in PAP at Tn 3, Tn 4 and Tn 5 (n P<0.05), where PAP was obviously higher at Tn 2 than those at other time points (n P<0.05). CVP was obviously higher at Tn 1 and Tn 2 than those at other time points (n P<0.05). CI at Tn 2 significantly decreased compared with those at other time points (n P<0.05). GEDI and ITBL at Tn 2 were significantly higher than those at Tn 0 and Tn 3 (n P0.05). There was a positive correlation between CVP and CI at Tn 0, Tn 4 and Tn 5 (n P<0.05). There was a positive correlation among GEDI, ITBI and CI at Tn 0 to Tn 5 (n P<0.05).n Conclusions:The correlations of GEDI and ITBI with CI are better than CVP during the anesthesia of lung transplantation.