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本文研究13例糖尿病肾病(DMN)的甲状腺激素变化,并以病情接近无肾功能受损的糖尿病人(DM)13例,肾功能损害程度相似的慢性肾小球肾炎患者(CRF)13例做对照。研究结果表明:DMN 与 DM 组除 T_3下降较一致外,T_4与 r-T_3之改变截然不同;DMN 与 CRF 组的甲功改变大同小异;DMN 的r-T_3与肾功能减退之程度关系密切。故糖尿病的甲功检测对于发现其是否合并肾功能减退、衡量 DMN 肾功能损害之严重程度均具有重要的意义。同时从 CRF 的 T_4改变机制,推测 T_4之动态观察有可能发现早期 DMN。
Thirteen patients with diabetic nephropathy (DMN) were studied for thyroid hormone. Thirteen patients with diabetic nephropathy (DM) who had no renal dysfunction and 13 patients with chronic glomerulonephritis (CRF) who had similar degree of renal dysfunction Control. The results showed that the changes of T_4 and r_T_3 were completely different except for the decrease of T_3 in DMN and DM groups. The changes of methylation in DMN and CRF groups were similar, and the level of r_T_3 in DMN was closely related to the degree of renal dysfunction. Therefore, diabetes mellitus test for the detection of whether it is associated with renal dysfunction, DMN measurement of the severity of renal damage are of great significance. At the same time from the T_4 CRF mechanism to change, speculated that the dynamic observation of T_4 may find early DMN.