对于抗肿瘤药物对癌症病人的不良影响,人们已有所了解,而对工作环境中经常接触低水平抗肿瘤药物对健康的影响尚有争议。本文调查了在同一肿瘤科工作的42名护士,每天接触5-氟尿嘧啶、环磷酰胺、甲氨喋呤、阿霉素和顺氯氨铂等抗癌药。并以从未接触过抗肿瘤药物的42名护士作为对照。为排除职业接触抗肿瘤药物以外的其他可能的诱变因素对研究结果的影响,作者调查了两组护士吸烟、服药、疾病、近期预防接种和接 It is well known that adverse effects of anti-cancer drugs on cancer patients are still debated, and the health effects of frequent exposure to low-level anti-cancer drugs in the work environment are still debated. In this study, 42 nurses working in the same oncology department were investigated daily for anticancer drugs such as 5-fluorouracil, cyclophosphamide, methotrexate, doxorubicin and cisplatin. Forty-two nurses who had never been exposed to antineoplastic drugs served as controls. In order to exclude the influence of occupational exposure to antineoplastic agents on other possible mutational factors, the authors investigated the prevalence of smoking, medication, illness, recent immunizations and access